Cardiac arrest & resuscitation
Different neuroprognostication thresholds of neuron-specific enolase in shockable and non-shockable out-of-hospital cardiac arrest: a prospective multicenter observational study in Korea (the KORHN-PRO registry)
An erratum to this article was published (Crit Care, 17 Jan 2025 ↗)
Authors' conclusion
NSE prognostic performance and its cutoff values with FPR < 1% for predicting poor outcome in OHCA survivors who underwent TTM differed between shockable and non-shockable rhythms, suggesting postcardiac arrest survivor heterogeneity.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management (TTM) with serum neuron-specific enolase (NSE) measured 48 h after ROSC, Korean Hypothermia Network, 22 university-affiliated hospitals, South Korea, October 2015–December 2018
- Participants
- 623 survivors
- Exposure
- NSE prognostic performance in non-shockable vs shockable initial rhythm
- Shockablen = 245reference
- Outcome
- Poor outcome (cerebral performance category 3-5)
- Follow-up
- 6 month
Methodological detailsmulticentre registry
- Multicentre registry
Main finding
As reported in the abstract
Prognostic performance of NSE for poor outcome; cutoff with FPR < 1%
| Group | AUC | NSE cutoff (false positive rate (FPR) < 1%) | Sensitivity |
|---|---|---|---|
| Non-shockable | 0.92 | 69.3 | 42.1% |
| Shockable | 0.86 | 102.7 ng/mL | 76% |
AUC
Non-shockable0.92
Shockable0.86
NSE cutoff (false positive rate (FPR) < 1%)
Non-shockable69.3
Shockable102.7 ng/mL
Sensitivity
Non-shockable42.1%
Shockable76%
Observational data: associations, not effects.
Further findings
Serum NSE level at 48 h
P < 0.001
Original publication
Different neuroprognostication thresholds of neuron-specific enolase in shockable and non-shockable out-of-hospital cardiac arrest: a prospective multicenter observational study in Korea (the KORHN-PRO registry). Crit Care. Published 9 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →