Cardiac arrest & resuscitation
Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial
Authors' conclusion
In this study, higher doses of propofol and the use of remifentanil and fentanyl were associated with good functional outcome and survival, occurrence of clinical seizures, and late awakening.
Study context
- Population
- OHCA patients randomised to normothermia or hypothermia in the TTM2 trial, with mandatory deep sedation (RASS ≤ −4) during the 40-h intervention1,861 analysed
- Participants
- 1,900 patients
- Comparison
- Cumulative propofol dose quartiles (Q1-Q4) and receipt of fentanyl or remifentanil
- Primary endpoint
- Good functional outcome (modified Rankin Scale)
- Follow-up
- 6 months
Methodological detailspost hoc analysis, multivariable logistic regression
- Post hoc analysis
- Multivariable logistic regression
Primary result
As reported in the abstract
Good functional outcome
Each group vs Q1Odds ratio (95% CI)
Q3multivariable logistic regression
1.62(1.12–2.34)
Fentanyl
1.69(1.27–2.26)
Remifentanil
1.50(1.11–2.02)
Further findings
| Outcome | Estimate | |
|---|---|---|
| Survival · 6 monthsQ2 vs Q1 · multivariable logistic regression | OR for survival 1.49 (95% CI 1.05–2.12) | |
| Survival · 6 monthsQ3 vs Q1 · multivariable logistic regression | OR for survival 1.84 (95% CI 1.27–2.65) | |
| Survival · 6 monthsFentanyl vs Q1 | OR for survival 1.80 (95% CI 1.35–2.40) | |
| Survival · 6 monthsRemifentanil vs Q1 | OR for survival 1.56 (95% CI 1.16–2.10) | |
| Clinical seizures during ICU stayFentanyl vs Q1 | OR for clinical seizures 0.64 (95% CI 0.48–0.86) | |
| Late awakening (FOUR motor score of 4 at 96 h)Q4 vs Q1 | OR for late awakening 3.19 (95% CI 1.91–5.42) | |
| 0.20.5125Ratio (log scale) |
Clinical seizures during ICU stay
- Higher propofol doses (Q2-4, 43.9-669.4 mg/kg) associated with occurrence of clinical seizures
Original publication
Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial. Crit Care. Published 17 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →