Cardiac arrest & resuscitation
Blood N1-methyladenosine (m1A) RNA modification and outcome after cardiac arrest
Performance · m¹A/A ratio and neurological outcome or deathResult — go to the resultOdds ratio 1.50 95% CI 1.04–2.19Authors' conclusion
This study provides the first evidence that m1A RNA methylation, reflected by the m1A/A ratio, is associated with neurological outcome and death at 6 months after CA.
Study context
- Population
- Patients after cardiac arrest, whole blood sampled 48 h after return of spontaneous circulation (ROSC)
- Participants
- 211 patients
- Comparison
- Higher vs lower blood m¹A/A ratio 48 h after ROSC
- Outcome
- Neurological outcome (CPC score) and survival
- Follow-up
- 6 months
Performance
m¹A/A ratio and neurological outcome or death
Odds ratio
1.50
95% CI 1.04–2.19
Higher m1A/A levels
OR 1.50 (95% CI 1.04–2.19)
As reported in the abstract
Further findings
| Outcome | P value |
|---|---|
| Survival (Kaplan-Meier) · 6 monthsLower probability of survival with elevated m¹A/A | P = 0.003 |
Original publication
Blood N1-methyladenosine (m1A) RNA modification and outcome after cardiac arrest. Crit Care. Published 25 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →