Cardiac arrest & resuscitation
Cerebral tissue oxygen saturation at defibrillation and return of spontaneous circulation in out-of-hospital cardiac arrest with a shockable rhythm
Main finding · SctO2 at first monitored defibrillationResult — go to the resultOdds ratio 1.48 95% CI 1.22–1.80Authors' conclusion
In this selected population, higher SctO2 at defibrillation was associated with ROSC.
Study context
- Population
- Adults with out-of-hospital cardiac arrest (OHCA) undergoing SctO2 monitoring during ongoing CPR and receiving in-hospital defibrillation for ventricular fibrillation or pulseless ventricular tachycardia194 monitored defibrillations
- Exposure
- SctO2 at first monitored defibrillation, return of spontaneous circulation (ROSC) vs no ROSC
- ROSCn = 19
- Outcome
- ROSC after the first monitored defibrillation, by SctO2 at that defibrillation
Methodological detailsmultivariable Firth penalized logistic regression, adjusted for site
- Multivariable Firth penalized logistic regression
- Adjusted for site
Main finding
SctO2 at first monitored defibrillation
Odds ratio
1.48
95% CI 1.22–1.80
P < 0.001
By group
ROSC
OR 1.48 (95% CI 1.22–1.80); P < 0.001
Per 1% increase in SctO2, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
Discrimination of SctO2 for ROSC (AUC; cut-off 44.5%)
- AUC
- 0.961 (95% CI 0.917-0.991)
- Sensitivity at SctO2 cut-off 44.5%
- 94.7% (18/19; 95% CI 74.0%-99.9%)
- Specificity at SctO2 cut-off 44.5%
- 89.7% (61/68; 95% CI 79.9%-95.8%)
- Exploratory cutoff
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cerebral tissue oxygen saturation at defibrillation and return of spontaneous circulation in out-of-hospital cardiac arrest with a shockable rhythm. Resuscitation. Published 31 August 2026. doi:10.
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