Cardiac arrest & resuscitation
Relationship between cortical electrical responsiveness and changes in regional cerebral oxygenation (rSO2) and return of spontaneous circulation in prolonged cardiac arrest: a multi-center observational study
Authors' conclusion
Near-physiologic brain activity may be restored during prolonged CPR if oxygenation thresholds are met and is associated with ROSC.
Study context
- Population
- Consecutive adults with IHCA monitored with EEG and near-infrared spectroscopy (rSO2) during cardiopulmonary resuscitation (CPR)53 interpretable EEG
- Participants
- 85 adults
- Exposure
- EEG patterns during CPR in relation to rSO2 and return of spontaneous circulation (ROSC)
- Outcome
- EEG patterns during prolonged CPR and rSO2 thresholds
Main finding
As reported in the abstract
- Diffuse cortical suppression (most common pattern)
- 47%
- Near-normal rhythms
- 40%
- Delta
- 22%
- Theta
- 12%
- Alpha
- 6%
- Pathologic activity
- 13%
- Delta and theta emerged at rSO2
- ≥16%
- Alpha emerged at rSO2
- >40%
- Alpha activity seen up to (min into CPR)
- 35 min
- Delta/theta seen up to (min into CPR)
- 60 min
- Suppression reverted to near-normal (of transitions)
- 12%
Observational data: associations, not effects.
Further findings
ROSC by EEG pattern
| OR (95% CI) | P value | ||
|---|---|---|---|
| Alpha activity | 5.4 (1.08–29.20) | P = 0.045 | |
| SuppressionLower ROSC odds | 0.12 (0.02–0.53) | P = 0.002 | |
| 0.050.21520Odds ratio (log scale) |
- Survival analysis limited by small sample size
Original publication
Relationship between cortical electrical responsiveness and changes in regional cerebral oxygenation (rSO2) and return of spontaneous circulation in prolonged cardiac arrest: a multi-center observational study. Resuscitation. Published 25 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →