Perioperative medicine & outcomes

Body Mass Index and Postsurgical Outcomes in Older Adults

JAMA Netw OpenPublished Prospective cohort study

An erratum to this article was published (JAMA Netw Open, 1 Oct 2025 ↗)

Authors' conclusion

In this observational cohort study of older adults undergoing major elective surgery, being overweight was associated with lower odds of 30-day all-cause mortality.

Study context

Population
Adults aged 65 years or older presenting to a preoperative clinic before planned major elective surgery, large academic center in Southern California, February 2019 to January 2022
Participants
414 adults
Exposure
Body mass index (BMI) categories: overweight and underweight vs normal BMI
  • Normal BMIn = 133reference
  • Overweightn = 128
  • Underweightn = 20
Outcome
All-cause mortality
Follow-up
30 days
Methodological detailssingle-centre
  • Single-centre

Main finding

As reported in the abstract

30-day all-cause mortality
Overweight vs Normal BMIOdds ratio (95% CI)P value
Unadjusted
0.03(0.01–0.26)
P = 0.001
Multivariable logistic regression, adjusted for potential confounders
0.14(0.06–0.34)
P < 0.001
Overall 30-day all-cause mortality rate
11.0%

Observational data: associations, not effects.

Original publication

Body Mass Index and Postsurgical Outcomes in Older Adults. JAMA Netw Open. Published 1 August 2025. doi:10.1001/jamanetworkopen.2025.28875

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