Pediatric anesthesia & critical care
Brachial Plexus Block Reduces Pain Scores During Peripherally Inserted Central Catheter Placement in Neonates and Pediatric Patients Compared to Local Infiltration Anesthesia: A Randomized, Double‐Blind, Single‐Center Study
Primary result · Comfort Neo Scale score at T = 0 (puncture)Result — go to the resultDifference −24 95% CI −24 to −24Authors' conclusion
Brachial plexus block provides superior pain relief and procedural outcomes compared to local infiltration anesthesia during peripherally inserted central catheter placement in neonates and pediatric patients.
Study context
- Population
- Neonates and pediatric patients undergoing peripherally inserted central catheter placement
- Participants
- 70 neonates
- Comparison
- Group B vs Group C
- Primary endpoint
- Procedural pain (Comfort Neo Scale)
- Follow-up
- T = 0 min (puncture) and T = 30 min (30 min after the procedure)
Methodological detailsdouble-blind, single-centre, ultrasound-guided
- Double-blind
- Single-centre
- Ultrasound-guided
Primary result
Comfort Neo Scale score at T = 0 (puncture) · T = 0
Difference
−24
95% CI −24 to −24
P < 0.0001
By group
Group B
6
median · IQR 6–6
Group C
30
median · IQR 30–30
Group B vs Group C
difference −24 (95% CI −24 to −24); P < 0.0001
As reported in the abstract
Secondary outcomes
Median
| Outcome | Group B | Group C | Difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Comfort Neo Scale score at T = 30 min | — not stated in the abstract | 22 (IQR 12–30) | −16 (−19 to −10) | P < 0.0001 | |
| Number of puncture attempts | 1 (IQR 1–2) | 2 (IQR 1–3) | −1 (−2 to 0) | P < 0.001 | |
| −20−10010Difference (linear scale) |
— not stated in the abstract
Median, min
| Outcome | Group B | Group C | Difference (min) (95% CI) | P value | |
|---|---|---|---|---|---|
| Procedure time | 30 (IQR 20–30) | 40 (IQR 30–50) | −10 (−20 to −10) | P < 0.0001 | |
| −30−20−10010Difference, min (linear scale) |
| Outcome | Group B | Group C | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| First-attempt success rate | 61% | 38% | 0.08 (0.03–0.26) | P < 0.0001 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value |
|---|---|---|
| Rescue analgesic use and pain-related movementsOR for pain-related movement | ∞ (109-∞) | P < 0.0001 |
Rescue analgesic use and pain-related movements
- Rescue analgesic use and pain-related movements significantly reduced in Group B
Original publication
Brachial Plexus Block Reduces Pain Scores During Peripherally Inserted Central Catheter Placement in Neonates and Pediatric Patients Compared to Local Infiltration Anesthesia: A Randomized, Double‐Blind, Single‐Center Study. Paediatr Anaesth. Published 16 September 2025. doi:10.
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