Neuroanesthesia & neurocritical care
Brain protective ventilation in acute brain injury patients with use of fully automated ventilation (BRAVE)): A cross-over clinical trial
Authors' conclusion
Automated ventilation outperformed conventional ventilation in maintaining protective ventilation targets for brain and lung in ABI patients.
Study context
- Population
- Acute brain injury patients receiving invasive mechanical ventilation, primary care hospital in Italy, 2024
- Participants
- 20 patients
- Exposure
- Automated ventilation vs conventional ventilation
- Outcome
- Percentage of breaths in three predefined zones of ventilatory targets (optimal, acceptable, critical), based on patient-specific ranges of EtCO2, SpO2, tidal volume and maximum airway pressure
Methodological detailssingle-centre
- Single-centre
Further findings
Optimal breaths by individual measure
- Optimal breaths increased for EtCO2, SpO2 and tidal volume, but declined for Pmax with automation
Percentage of time in each ventilation zone
- Mirrored the percentage of breaths in each zone
Original publication
Brain protective ventilation in acute brain injury patients with use of fully automated ventilation (BRAVE)): A cross-over clinical trial. Eur J Anaesthesiol. Published 22 August 2025. doi:10.
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