Neuroanesthesia & neurocritical care
Brain tissue oxygen monitoring in traumatic brain injury: part I—To what extent does PbtO2 reflect global cerebral physiology?
Authors' conclusion
PbtO2 below 20 mmHg was relatively frequent and often occurred in the absence of disturbances in ICP, PRx, CPP, and ∆CPPopt. There were significant, but weak associations between the global cerebral physiological variables and pbtO2, suggesting that hypoxic pbtO2 is often a complex and independent pathophysiological event.
Study context
- Population
- Traumatic brain injury (TBI) patients with intracranial pressure (ICP) and pbtO2 monitoring for at least 12 h, neurocritical care unit, Addenbrooke's Hospital, Cambridge, UK, 2002–2022
- Participants
- 425 patients
- Outcome
- Association of ICP, PRx, CPP and ∆CPPopt (actual CPP-CPPopt) with brain tissue oxygenation (pbtO2)
Methodological detailssingle-centre, generalized additive models, linear mixed effect models
- Single-centre
- Generalized additive models
- Linear mixed effect models
Main finding
As reported in the abstract
PbtO2 < 20 mmHg, median proportion of monitoring time
17%
PbtO2 < 20 mmHg combined with ICP > 20 mmHg, PRx > 0.30, cerebral perfusion pressure (CPP) < 60 mmHg, or ∆CPPopt < - 5 mmHg, proportion of monitoring time
less than 5%
Observational data: associations, not effects.
Original publication
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