Neuroanesthesia & neurocritical care
Brain tissue oxygen monitoring in traumatic brain injury—part II: isolated and combined insults in relation to outcome
Authors' conclusion
Low pbtO2, under 25 mmHg and particularly below 15 mmHg, for longer durations and in combination with disturbances in global cerebral physiological variables were associated with poor outcome and may indicate detrimental ischaemic hypoxia.
Study context
- Population
- Traumatic brain injury (TBI) patients with intracranial pressure (ICP) and pbtO2 monitoring for at least 12 h, neurocritical care unit, Addenbrooke's Hospital, Cambridge, UK, 2002–2022
- Participants
- 239 patients
- Outcome
- Outcome (GOS favourable/unfavourable 4-5/1-3; survival/mortality 2-5/1) in relation to isolated and combined threshold-insults for brain tissue oxygenation (pbtO2) in TBI
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
pbtO2 threshold yielding highest x2 for favourable/unfavourable outcome
25 mmHg
pbtO2 threshold yielding highest x2 for mortality/survival
20 mmHg
Observational data: associations, not effects.
Original publication
Brain tissue oxygen monitoring in traumatic brain injury—part II: isolated and combined insults in relation to outcome. Crit Care. Published 26 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →