Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials
Pooled result · Pain intensityResult — go to the resultHedges's g −0.36 95% CI −0.59 to −0.14Authors' conclusion
Buprenorphine demonstrated superior efficacy in managing acute postoperative pain compared with FAOs, with a favorable safety profile and longer duration of action.
Study context
- Population
- Adults with acute postoperative pain41 comparisons
- Participants
- 2,587 adults
- Comparison
- Buprenorphine vs other opioids
- Outcome
- Pain intensity
Methodological detailsrandom-effects meta-analysis, Risk of bias low in 19 studies, some concerns in 37, high in 2
- Random-effects meta-analysis
- Risk of bias low in 19 studies, some concerns in 37, high in 2
Pooled result
As reported in the abstract
Hedges's g
−0.36
95% CI −0.59 to −0.14
P < 0.001
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Pain intensity, vs full agonist opioid (FAO) alone95% PI=−1.76 to 1.07 | −0.34 (−0.59 to −0.10) | P < 0.001 | |
| −1−0.500.5Difference (linear scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Rescue analgesia requirement95% PI=0.12 to 1.36 | 0.40 (0.26–0.63) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
- Rescue analgesia requirement: I2=38.93%, 95% CI=1.44% to 64.37% (moderate inconsistency)
Duration of analgesia
- Mean duration of analgesia
- 8.5 hours (SD 1.84)
Safety
Adverse effects incl. nausea and respiratory depression
- No significant differences
Original publication
Buprenorphine versus full agonist opioids for acute postoperative pain management: a systematic review and meta-analysis of randomized controlled trials. Reg Anesth Pain Med. Published 2 January 2025. doi:10.
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