Cannabis use and acute postoperative pain outcomes in older adults: a propensity matched retrospective cohort study
Authors' conclusion
This study showed that cannabis use in older adults was associated with increased postoperative pain levels and opioid doses.
Study context
- Population
- Older surgical patients with at least 24-hour hospital stays, University of Florida Health, 2018–2020propensity-matched
- Participants
- 504 patients
- Exposure
- Cannabis users vs non-users
- Cannabis usersn = 126
- Non-usersn = 378reference
- Outcome
- Average Defense and Veterans Pain Rating Scale (DVPRS) score and total oral morphine equivalents (OME)
- Follow-up
- Within 24 hours of surgery
Methodological detailspropensity score-matched, 1:3 matching
- Propensity score-matched
- 1:3 matching
Main finding
As reported in the abstract
Cannabis users
4.68
median · IQR 2.71–5.96
Non-users
3.88
median · IQR 2.33–5.17
Cannabis users vs Non-usersDifference (95% CI)P value
Average DVPRS score; 95% confidence limit
0.80(0.19–1.36)
P = 0.01Cannabis users vs Non-usersDifference, mg (95% CI)P value
Total OME; 95% confidence limit
12.5(3.80 mg to 21.20 mg)
P = 0.02Observational data: associations, not effects.
Original publication
Cannabis use and acute postoperative pain outcomes in older adults: a propensity matched retrospective cohort study. Reg Anesth Pain Med. Published 30 June 2024. doi:10.
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