Impact of Neuraxial Preservative-Free Morphine in Vaginal Delivery on Opiate Consumption and Recovery: A Randomized Control Trial
Authors' conclusion
A single epidural dose of 2 mg preservative-free morphine after VD was effective at decreasing pain and opioid use at 24 hours after VD but came at the cost of increased pruritus.
Study context
- Population
- Parturients who delivered vaginally with epidural analgesiaanalysed
- Participants
- 157 participants
- Comparison
- Morphine vs Saline
- Morphinen = 80
- Salinen = 77reference
- Primary endpoint
- Opiate consumption
- Follow-up
- First 24 hours after drug administration
Primary result
As reported in the abstract
Opioid use · first 24 hours
Secondary outcomes
| Outcome | Morphine | Saline | P value |
|---|---|---|---|
| Total opioid dose (MME) · first 24 hours | median 0 (IQR [range] 0-0 [0-47.5]) morphine milligram equivalent | median 0 (IQR [range] 0-0 [0-72]) morphine milligram equivalent | P = 0.023 |
| Verbal pain scores (0-10) · 24 hoursLower in the morphine group · median | 2.0 (IQR [range] 1-4 [0-10]) | 3.0 (IQR [range] 1.5-5.0 [0-10]) | P = 0.043 |
OBS-QOR10, breastfeeding (BF) success, Edinburgh Postnatal Depression Score (EPDS) · 6 weeks PP
- No differences found
Safety
| Outcome | Morphine | Saline | P value |
|---|---|---|---|
| Pruritus | 37.5% (95% CI 27.1%–49.1%) | 18.2% (95% CI 10.6%–29.0%) | P = 0.008 |
Original publication
Impact of Neuraxial Preservative-Free Morphine in Vaginal Delivery on Opiate Consumption and Recovery: A Randomized Control Trial. Anesth Analg. Published 1 May 2025. doi:10.
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