Cardiac arrest & resuscitation
Capnometry predicts the viability of procured kidneys from uncontrolled donation after circulatory death donors
Authors' conclusion
Capnometry obtained at hospital arrival is useful for identifying valid uDCD donors. In addition, younger donor age, use of mechanical chest compression devices, and transient return of pulse are prehospital variables that also increase the odds of viability in this type of donors.
Study context
- Population
- Potential uncontrolled donation after circulatory death (uDCD) donors after unsuccessful out-of-hospital cardiopulmonary resuscitation (CPR), 2018–2023
- Participants
- 69 participants
- Exposure
- Valid vs futile uDCD donors
- Validn = 26
- Futilen = 43reference
- Outcome
- Capnometry values discriminating valid from futile uDCD donors
- Follow-up
- Start of CPR, midpoint and hospital arrival (transfer)
Methodological detailstwo transplant centres
- Two transplant centres
Main finding
As reported in the abstract
Capnometry
| Group | Initial reading | At transfer |
|---|---|---|
| Valid | 24.5 mmHg | 26 mmHg |
| Futile | 16 mmHg | 15 mmHg |
Initial reading
Valid24.5 mmHg
Futile16 mmHg
At transfer
Valid26 mmHg
Futile15 mmHg
- Valid vs Futile: P < 0.078 — initial reading
- Valid vs Futile: P < 0.004 — at transfer
- Optimal cut-off for transfer capnometry to discriminate viable from futile donors
- 17 mmHg
Observational data: associations, not effects.
Further findings
Independent predictors of donor viability (multivariable model)
- Mechanical chest compression, OR
- 14.29; P-value = 0.009
- Transient return of pulse, OR
- 19.0; P-value = 0.013
- Donor age, OR per one-year increase
- 0.91; P-value = 0.026
- Capnometry at hospital arrival, OR per one-mmHg increase
- 1.08, P-value = 0.012
Original publication
Capnometry predicts the viability of procured kidneys from uncontrolled donation after circulatory death donors. Resuscitation. Published 20 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →