Cardiac arrest & resuscitation
Does cardiopulmonary resuscitation before donor death affect solid organ transplant function? A systematic review and meta-analysis
Authors' conclusion
Organs transplanted from donors who received CPR demonstrated comparable outcomes at the longest follow-up compared to organs from donors who did not receive CPR. Kidneys and livers after uncontrolled donation after circulatory death showed worse outcomes compared to donation after brain death.
Study context
- Population
- Recipients of solid organs transplanted from deceased donors, analysed separately by organ and pathway (brain/circulatory death)33 studies (donors)
- Participants
- 72,994 recipients
- Comparison
- Organs from donors who underwent cardiopulmonary resuscitation (CPR) vs donors who did not receive CPR
- Outcome
- Graft survival
- Follow-up
- Longest
Pooled result
As reported in the abstract
Graft survival at longest follow-up
- Brain-dead donors with vs without CPR (24 studies, all organs): outcomes did not differ between groups
Further pooled results
| Outcome | OR of graft survival (CI) | |
|---|---|---|
| Long-term graft survival, livers: uncontrolled donation after circulatory death vs donation after brain death (9 studies) · longest follow-upLower graft survival after uncontrolled circulatory death | 0.51 (0.32–0.83) | |
| Graft survival, kidneys: uncontrolled donation after circulatory death vs donation after brain death (9 studies) · longest follow-upLong-term graft survival not lower | 0.64 (0.36–1.15) | |
| Long-term graft survival, kidneys: controlled vs uncontrolled donation after circulatory death (2 studies) · longest follow-upNo different long-term graft survival | 0.73 (0.27–1.99) | |
| 0.20.5125OR of graft survival (log scale) |
Graft survival, kidneys: uncontrolled donation after circulatory death vs donation after brain death (9 studies) · longest follow-up
- Lower short-term graft survival after uncontrolled circulatory death
Original publication
Does cardiopulmonary resuscitation before donor death affect solid organ transplant function? A systematic review and meta-analysis. Resuscitation. Published 21 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →