Cardiac arrest & resuscitation
Hypothermia or Machine Perfusion in Kidney Donors
Authors' conclusion
Among brain-dead organ donors, therapeutic hypothermia was inferior to machine perfusion of the kidney in reducing delayed graft function after transplantation. The combination of hypothermia and machine perfusion did not provide additional protection.
Study context
- Population
- Brain-dead kidney donors at six US organ-procurement facilities and their kidney transplant recipients
- Participants
- 1,349 kidneys
- Comparison
- Hypothermia vs Machine perfusion vs Combination therapy
- Hypothermian = 359
- Machine perfusionn = 511reference
- Combination therapyn = 479
- Primary endpoint
- Delayed graft function (initiation of dialysis during the first 7 days after transplantation)
- Follow-up
- First 7 days after transplantation
Methodological detailsmulticentre, three-arm, non-inferiority and superiority comparisons
- Multicentre
- Three-arm
- Non-inferiority and superiority comparisons
Primary result
As reported in the abstract
Adjusted relative risk (95% CI)
Hypothermia vs Machine perfusion
1.72(1.35–2.17)
Hypothermia vs Combination therapy
1.57(1.26–1.96)
Combination therapy vs Machine perfusion
1.09(0.85–1.40)
Secondary outcomes
Graft survival · 1 year
- Similar in the three groups
Safety
- Total adverse events
- 10
- Cardiovascular instability (donors)
- 9
- Organ loss owing to perfusion malfunction (donors)
- 1
Original publication
Hypothermia or Machine Perfusion in Kidney Donors. N Engl J Med. Published 2 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →