Neuroanesthesia & neurocritical care
Evidence-Based Checklist to Delay Cardiac Arrest in Brain-Dead Potential Organ Donors: The DONORS Cluster Randomized Clinical Trial
Primary resultResult — go to the resultRelative risk 0.70 95% CI 0.46–1.08Authors' conclusion
This cluster randomized clinical trial was inconclusive in determining whether the overall use of an evidence-based, goal-directed checklist reduced brain-dead potential donor loss to cardiac arrest.
Study context
- Population
- Consecutive brain-dead potential donors aged 14 to 90 years in intensive care unit (ICUs) (≥10 brain deaths in previous 2 years) in Brazil
- Participants
- 1,535 donors · 63 hospitals
- Comparison
- Evidence-based, goal-directed checklist vs usual care
- Interventionn = 743
- Controln = 792reference
- Primary endpoint
- Loss of brain-dead potential donors to cardiac arrest at the individual level
Methodological detailsopen-label, parallel-group, multicentre, Enrollment and follow-up June 20, 2017, to November 30, 2019
- Open-label
- Parallel-group
- Multicentre
- Enrollment and follow-up June 20, 2017, to November 30, 2019
Primary result
As reported in the abstract
Relative risk
0.70
95% CI 0.46–1.08
P = 0.11
Events by treatment group
Intervention vs Control
RR 0.70 (95% CI 0.46–1.08); P = 0.11
Further findings
| Outcome | Control | RR (95% CI) | P value | |
|---|---|---|---|---|
| Primary outcome, adherence >79.0% vs control (prespecified sensitivity analysis) | 14.8% | 0.41 (0.22–0.78) | P = 0.006 | |
| 0.20.5125Relative risk (log scale) |
- Primary outcome, adherence >79.0% vs control (prespecified sensitivity analysis): Adherence >79.0% 5.3%
Original publication
Evidence-Based Checklist to Delay Cardiac Arrest in Brain-Dead Potential Organ Donors: The DONORS Cluster Randomized Clinical Trial. JAMA Netw Open. Published 1 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →