Cardiac ultrasound-guided crystalloid preloading before spinal anesthesia vs. standard coloading for scheduled cesarean delivery: a randomized controlled trial
Primary result · Hypotension incidenceResult — go to the resultRelative risk 0.6 95% CI 0.39–0.91Authors' conclusion
Ultrasound-guided preload correction plus coloading reduces hypotension incidence, duration, rescue fluids, and maternal side effects in preload-dependent patients.
Study context
- Population
- ASA II women with singleton pregnancies scheduled for elective cesarean under spinal anesthesia, preload dependent (ΔLVOT VTI ≥ 12% after passive leg raising), Tunis Maternity Center
- Participants
- 96 women
- Comparison
- A vs C
- An = 48
- Cn = 48reference
- Primary endpoint
- Hypotension incidence (SBP decrease > 20% baseline)
Methodological detailssingle-centre
- Single-centre
Primary result
Hypotension incidence
Relative risk
0.6
95% CI 0.39–0.91
P < 0.001
By group
A vs C
RR 0.6 (95% CI 0.39–0.91); P < 0.001
As reported in the abstract
Secondary outcomes
Hypotension duration
P = 0.012
Lowest SBP
P < 0.001
Rescue crystalloids
P = 0.04
| Outcome | A | C | P value |
|---|---|---|---|
| Umbilical pH | 7.34 ± 0.06 | 7.28 ± 0.06 | P = 0.02 |
Ephedrine use and cardiac output
- Similar in the two groups
Safety
Nausea/vomiting
P = 0.01
Original publication
Cardiac ultrasound-guided crystalloid preloading before spinal anesthesia vs. standard coloading for scheduled cesarean delivery: a randomized controlled trial. Int J Obstet Anesth. Published 29 December 2025. doi:10.
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