Cardiac arrest & resuscitation
Cardiovascular changes induced by targeted mild hypercapnia after out of hospital cardiac arrest. A sub-study of the TAME cardiac arrest trial
Authors' conclusion
In resuscitated OHCA patients, targeting mild hypercapnia did not increase PVRI or worsen right ventricular function compared to normocapnia. Mild hypercapnia comparatively improved cardiac performance and mixed venous oxygen saturation.
Study context
- Population
- Patients resuscitated from out-of-hospital cardiac arrest (OHCA)
- Participants
- 84 patients
- Comparison
- Targeted mild hypercapnia vs targeted normocapnia
- Primary endpoint
- Pulmonary vascular resistance and RV function (right heart catheterisation)
- Follow-up
- Every 4th hour for 48 hours
Methodological detailspre-planned, single-centre, prospective
- Pre-planned
- Single-centre
- Prospective
Primary result
As reported in the abstract
PVRI, pulmonary artery pulsatility index, right atrial pressure
- Pulmonary vascular resistance index (PVRI), pulmonary artery pulsatility index and right atrial pressure did not differ between groups
- P-group > 0.05
Further findings
Cardiac index
P-group < 0.001
Systemic vascular resistance index
P-group < 0.001
Mean
| Outcome | Mild hypercapnia | Normocapnia | P value |
|---|---|---|---|
| pH | 7.24 (95% CI 7.22–7.30) | 7.32 (95% CI 7.31–7.34) | P-group < 0.001 |
Stroke volume and mixed venous oxygen saturation
- Stroke volumes higher with hypercapnia
- P-group = 0.013
- Mixed venous oxygen saturation higher with hypercapnia
- P-group < 0.001
Original publication
Cardiovascular changes induced by targeted mild hypercapnia after out of hospital cardiac arrest. A sub-study of the TAME cardiac arrest trial. Resuscitation. Published 15 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →