Cardiac arrest & resuscitation
Effects of mild hypercapnia on myocardial injury after out-of-hospital cardiac arrest. A sub-study of the TAME trial
Authors' conclusion
Mild hypercapnia was not associated with increased myocardial injury in resuscitated OHCA-patients. In AMI-patients, mild hypercapnia was associated with lower hs-cTnT and lactate, and improved cardiac performance.
Study context
- Population
- Comatose resuscitated out-of-hospital cardiac arrest (OHCA) patients after emergency coronary intervention57 (46%) with AMI
- Participants
- 125 participants
- Comparison
- Mild hypercapnia vs normocapnia
- Primary endpoint
- Myocardial injury (peak hs-cTnT) in AMI patients
- Follow-up
- Baseline, 24, 48 and 72 h
Methodological detailssingle-centre, prospective, pre-planned sub-study
- Single-centre
- Prospective
- Pre-planned sub-study
Primary result
As reported in the abstract
Peak hs-cTnT in AMI patients
P = 0.007
Further findings
Average area under hs-cTnT curve (AMI)
P-group = 0.002
Cardiac power output and lactate (AMI)
- Hypercapnia associated with increased cardiac power output (CPO) and lower lactate
- P-group < 0.05
High-sensitive cardiac troponin T (hs-cTnT), lactate, CPO (no AMI)
- Not significantly different between groups
- P > 0.05
Original publication
Effects of mild hypercapnia on myocardial injury after out-of-hospital cardiac arrest. A sub-study of the TAME trial. Resuscitation. Published 25 June 2024. doi:10.
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