Cardiac arrest & resuscitation
Effects of mild hypercapnia on myocardial injury among ST-elevation myocardial infarction patients after out-of-hospital cardiac arrest: a exploratory post-hoc study of the TAME trial
Authors' conclusion
Among STEMI patients of the TAME trial, myocardial injury, in-hospital mortality, and neurological outcome at six months were not modified by allocation to targeted mild hypercapnia.
Study context
- Population
- Comatose adults with STelevation myocardial infarction (STEMI) after out-of-hospital cardiac arrest (OHCA) in the TAME trialSTEMI
- Participants
- 593 adults
- Comparison
- Targeted mild hypercapnia vs normocapnia
- Mild hypercapnian = 287
- Normocapnian = 306reference
- Primary endpoint
- Myocardial injury: peak high-sensitivity cardiac troponin T (hs-cTnT) or cTnI during hospitalisation in STEMI and successfully PCI-treated STEMI patients
- Follow-up
- During hospitalisation
Methodological detailspost-hoc, exploratory
- Post-hoc
- Exploratory
Primary result
As reported in the abstract
Troponin level (ratio of geometric means, mild hypercapnia/normocapnia)
Each group vs normocapniaEstimate (95% CI)
Mild hypercapnia
ratio of geometric means, cTnI 1.18(0.79–1.77)
Mild hypercapnia
ratio of geometric means, hs-cTnT 1.20(0.88–1.63)
Secondary outcomes
| Outcome | Mild hypercapnia | Normocapnia | RR (95% CI) | |
|---|---|---|---|---|
| In-hospital mortality (STEMI) | 39% | 40.5% | 0.97 (0.82–1.14) | |
| Favourable neurological outcome · six months | 44.3% | 48.5% | 1.09 (0.92–1.29) | |
| 0.512Relative risk (log scale) |
- Favourable neurological outcome: 129 of 267 vs 125 of 282
Lactate clearance · first 24 h
- No difference according to treatment allocation
All outcomes, successful percutaneous coronary intervention (PCI) STEMI (subgroup)
- No significant differences in any outcomes according to treatment allocation
Original publication
Effects of mild hypercapnia on myocardial injury among ST-elevation myocardial infarction patients after out-of-hospital cardiac arrest: a exploratory post-hoc study of the TAME trial. Resuscitation. Published 21 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →