Respiratory failure & ventilation
Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure
Authors' conclusion
The ELF concentrations of IL-6, IL-8, IL-17A, IL-25, and IL-31 were significantly increased in COVID-19 patients.
Study context
- Population
- Patients with acute hypoxemic respiratory failure (AHRF) secondary to severe COVID-19, intubated for mechanical ventilation
- Participants
- 27 patients
- Exposure
- COVID-19 AHRF patients vs healthy volunteers
- COVID-19n = 27
- Outcome
- Concentrations of 25 cytokines in bronchial epithelial lining fluid (ELF) and plasma
- Follow-up
- Just after intubation
Methodological detailsEpithelial lining fluid (ELF) collected by bronchial microsampling through ETT just after intubation
- ELF collected by bronchial microsampling through ETT just after intubation
Main finding
As reported in the abstract
ELF cytokine concentrations, COVID-19 patients
| Group | Value | IL-6 | IL-8 | IL-17A | IL-25 | IL-31 |
|---|---|---|---|---|---|---|
| COVID-19 | median 27.6 pmol/L | 27.6 | 1045.1 | 0.8 | 1.5 | 42.3 |
COVID-19
Valuemedian 27.6 pmol/L
IL-627.6
IL-81045.1
IL-17A0.8
IL-251.5
IL-3142.3
Observational data: associations, not effects.
Further findings
Plasma cytokines
- MCP-1 and MIP-1β significantly greater in plasma of COVID-19 patients vs volunteers
ELF/plasma ratio (median)
- IL-8 (highest of 25 cytokines)
- 737
- IL-6
- 218
- IL-1β
- 202
- IL-31
- 169
- MCP-1
- 81
- MIP-1β
- 55
- TNF-α
- 47
Original publication
Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure. Crit Care. Published 23 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →