Pediatric anesthesia & critical care
Catheter-related Internal Jugular Vein Thrombosis in Neonates and Long-term Consequences: A Prospective Cohort Study
Authors' conclusion
Covert central venous thrombosis is frequent in neonates who have central venous catheters, and complications are most common in patients who have large intravascular thrombi.
Study context
- Population
- Neonates aged <28 days scheduled for major intestinal or cardiac surgery, expected to need central venous catheters for ≥48 h
- Participants
- 188 neonates
- Outcome
- Incidence of central venous catheter-related thrombosis (color Doppler ultrasound within 48 h after catheter removal)
Methodological detailsUltrasound results not shared with clinicians, Ultrasound repeated 1, 3 and 6 months after discharge, Catheter size, insertion method, puncture site and duration determined clinically
- Ultrasound results not shared with clinicians
- Ultrasound repeated 1, 3 and 6 months after discharge
- Catheter size, insertion method, puncture site and duration determined clinically
Main finding
As reported in the abstract
Central venous thrombi at catheter site
All neonates
68%
128 events
Observational data: associations, not effects.
Further findings
Vessel status at 6 months after discharge (patients with thrombi)
- Vessel status at 6 months after discharge (patients with thrombi) — Thrombi spontaneously resolved by 6 months
- 73%
Independent risk factors for vessel thrombus
- Catheter to vein diameter ratio, duration of catheterization and catheter dysfunction were independent risk factors
Complete vessel occlusion by initial thrombus size
- Most common when thrombus occupied >58% of the vessel at initial assessment
Duration of catheter insertion
- Median duration of catheter insertion
- 12 days
Original publication
Catheter-related Internal Jugular Vein Thrombosis in Neonates and Long-term Consequences: A Prospective Cohort Study. Anesthesiology. Published 4 October 2024. doi:10.
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