Cefazolin administration prior to caesarean delivery and breastmilk microbiome: a nested cohort within a randomised clinical trial
Authors' conclusion
In this small, restricted sample, cefazolin exposure prior to delivery exerted modest effects on the breastmilk microbiome.
Study context
- Population
- Adult females having caesarean delivery, Australiabreastmilk samples
- Comparison
- Pre-incision cefazolin vs placebo
- Primary endpoint
- Breastmilk microbiome composition (long-read 16S rRNA sequencing)
- Follow-up
- POD 14 and 30
Methodological detailsplacebo-controlled, long-read 16S rRNA sequencing
- Placebo-controlled
- Long-read 16S rRNA sequencing
Primary result
As reported in the abstract
Breastmilk microbiome composition
- Cefazolin exposure associated with altered composition: increased Roseateles spp. and Cutibacterium acnes, predominance of Gram-negative taxa
- Communities relatively static, enriched with less-characterised, environmentally associated genera
- Samples: Cefazolin 12 (day 14), 13 (day 30); Placebo 11 (day 14), 9 (day 30)
Original publication
Cefazolin administration prior to caesarean delivery and breastmilk microbiome: a nested cohort within a randomised clinical trial. Int J Obstet Anesth. Published 30 June 2026. doi:10.
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