Dexamethasone for prevention of spinal hypotension during caesarean delivery: a randomised controlled trial
Authors' conclusion
A single preoperative intravenous dose of dexamethasone 8 mg significantly reduced the incidence of spinal hypotension in patients undergoing caesarean delivery.
Study context
- Population
- Women undergoing elective caesarean delivery under spinal anaesthesia
- Participants
- 170 women
- Comparison
- Single preoperative IV dexamethasone 8 mg vs normal saline
- Group Dn = 85
- Group Cn = 85reference
- Primary endpoint
- Incidence of spinal hypotension
Primary result
As reported in the abstract
Difference
20 %
95% CI 6.72–33.28
P = 0.007
By group
Group D vs Group C
difference 20 % (95% CI 6.72–33.28); P = 0.007
Secondary outcomes
Post-delivery hypotension
- Not different between the groups
Phenylephrine requirement
- Significantly less in Group D
- P < 0.05
Safety
Nausea and/or vomiting, shivering
- Significantly less in Group D
- P < 0.05
Maternal bradycardia
- Not different between the groups
Maternal random blood sugar, neonatal Apgar scores, umbilical arterial pH
- No significant difference between groups
Original publication
Dexamethasone for prevention of spinal hypotension during caesarean delivery: a randomised controlled trial. Int J Obstet Anesth. Published 15 October 2024. doi:10.
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