Cardiac arrest & resuscitation
Cerebral monitoring responses to bedside physiological challenges in comatose post–cardiac arrest patients
Authors' conclusion
Brief physiological challenges simulating common ICU scenarios elicited only modest increases in StO₂, and no measurable response in EEG amplitude.
Study context
- Population
- Comatose post-cardiac arrest patients in the intensive care unit (ICU)
- Participants
- 41 / 33 / 32
- Comparison
- Bedside physiological challenges: FiO2 to 100%, head-of-bed lowered to 0°, etCO₂ raised by 1.0 kPa
- FiO2n = 41
- Head-of-bed (HOB)n = 33
- etCO₂n = 32
- Outcome
- Cerebral tissue oxygen saturation (StO₂, near-infrared spectroscopy (NIRS)) and EEG amplitude (frontal single-channel EEG) responses to the challenges
Methodological detailsChallenges completed in 41 (85%), 33 (69%) and 32 (67%) patients, respectively
- Challenges completed in 41 (85%), 33 (69%) and 32 (67%) patients, respectively
Main finding
As reported in the abstract
StO₂ and EEG amplitude responses
StO₂ increase per 10% rise in FiO2
0.3%
95%-CI 0.2–0.5p < 0.001
StO₂ increase per 15º lowering of the HOB
1.94%
95%-CI 0.9–3.0p < 0.001
Further findings
Responses by cerebral autoregulation status (intact vs impaired) and ICU outcome
- No significant differences in responses between intact vs impaired autoregulation or between ICU outcome groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cerebral monitoring responses to bedside physiological challenges in comatose post–cardiac arrest patients. J Clin Monit Comput. Published 10 December 2025. doi:10.
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