Pediatric anesthesia & critical care
Cerebrovascular Pressure Reactivity Has a Strong and Independent Association With Outcome in Children With Severe Traumatic Brain Injury*
Authors' conclusion
PRx had a strong association with outcome that was independent of ICP, CPP, GCS, and age.
Study context
- Population
- Children (≤ 14 yr) with severe TBI (postresuscitation Glasgow Coma Scale (GCS) ≤ 8) and intracranial pressure (ICP) monitoring, Red Cross War Memorial Children's Hospital, Cape Town, South Africa
- Participants
- 196 children
- Outcome
- PRx and mortality
Methodological detailssingle-centre, observational, Over 1.7 million minutes (28,634 hr) of mean arterial pressure (MAP) and ICP data analysed; ICM+ files sampled at 100Hz
- Single-centre
- Observational
- Over 1.7 million minutes (28,634 hr) of MAP and ICP data analysed; ICM+ files sampled at 100Hz
Main finding
As reported in the abstract
PRx consistently higher in patients with poor outcome; strong, independent association with mortality (ROC AUC)
0.91
Best PRx threshold for predicting mortality
0.25
Observational data: associations, not effects.
Further findings
Mortality and unfavorable outcome (series)
- Mortality
- 10.7% (21/196)
- Unfavorable outcome
- 29.6% (58/196)
Correlation of PRx with physiologic variables
- Moderate positive correlation with ICP, r (p < 0.001)
- 0.44
- Moderate negative correlation with cerebral perfusion pressure (CPP), r (p < 0.001)
- −0.43
- Weak negative correlation with MAP, r (p = 0.004)
- −0.21
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cerebrovascular Pressure Reactivity Has a Strong and Independent Association With Outcome in Children With Severe Traumatic Brain Injury*. Crit Care Med. Published 15 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →