Pediatric anesthesia & critical care
Anesthesia‐Related Adverse Events in Infants With Gastroschisis at a South African Tertiary Pediatric Hospital: A Retrospective Cohort Study
Authors' conclusion
ARAEs are common in infants with gastroschisis, particularly during pathology-related procedures.
Study context
- Population
- Infants with gastroschisis admitted to Red Cross War Memorial Children's Hospital, South Africa, 2012–2021196 general anesthetics
- Participants
- 65 infants
- Exposure
- Pathology-related surgery vs central venous catheter (CVC) procedures
- Outcome
- Incidence and nature of anesthesia-related adverse events (ARAEs; APRICOT and NECTARINE criteria)
Methodological detailssingle-centre, generalized estimating equations for repeated anesthetic exposures
- Single-centre
- Generalized estimating equations for repeated anesthetic exposures
Main finding
As reported in the abstract
ARAEs
Procedures with anesthesia-related adverse events (ARAEs)
79
40.3%
Patients with ARAEs
51
78.5%
Observational data: associations, not effects.
Further findings
| Outcome | Pathology-related surgery | CVC procedures | Adjusted OR (95% CI) | P value | |
|---|---|---|---|---|---|
| ARAEs by procedure type | 45.7% | 12.5% | 0.17 (0.08–0.35) | P < 0.001 | |
| 0.050.21520Adjusted odds ratio (log scale) |
GA solely for CVC procedures
- Infants with 4 or more GAs for CVC procedures alone
- 16
- General anesthetics per patient, median (IQR)
- 2 (1-4)
Original publication
Anesthesia‐Related Adverse Events in Infants With Gastroschisis at a South African Tertiary Pediatric Hospital: A Retrospective Cohort Study. Paediatr Anaesth. Published 12 December 2025. doi:10.
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