Perioperative medicine & outcomes
Changes of perioperative cognitive function and its effect on quality of life in laryngeal cancer
Authors' conclusion
LSCC patients exhibit a high prevalence of cognitive dysfunction, which significantly associated with reduced overall QoL. Age, postoperative anxiety, operation mode, and preoperative MoCA score were significantly associated with postoperative cognitive dysfunction.
Study context
- Population
- Patients with laryngeal squamous cell carcinoma (LSCC) treated with radical surgery
- Participants
- 88 patients
- Exposure
- Before vs after surgery
- Outcome
- Association between perioperative changes in cognitive function (MoCA) and QoL (EORTC QLQ-C30)
Main finding
As reported in the abstract
MoCA score
Before surgery
24.78
± 2.42
After surgery
23.02
± 3.06
P < 0.001
- Poorer overall health function scale quality of life (QoL) score in patients with postoperative cognitive impairment
- P = 0.030
Observational data: associations, not effects.
Further findings
Cognitive impairment
Independent factors for preoperative cognitive dysfunction
- Age
- P = 0.003
- Preoperative anxiety
- P = 0.016
Factors associated with postoperative cognitive dysfunction
- Age
- P = 0.023
- Postoperative anxiety
- P = 0.041
- Operation mode
- P = 0.05, p = 0.016 respectively
- Preoperative Montreal Cognitive Assessment (MoCA) score
- P = 0.008
Original publication
Changes of perioperative cognitive function and its effect on quality of life in laryngeal cancer. Perioper Med (Lond). Published 13 March 2025. doi:10.
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