Cardiothoracic & vascular anesthesia
Preoperative neutrophil–to–lymphocyte ratio after chemoradiotherapy for esophageal squamous cell carcinoma associates with postoperative pulmonary complications following radical esophagectomy
Authors' conclusion
Elevated preoperative neutrophil-to-lymphocyte ratio after chemoradiotherapy is independently associated with higher pulmonary complication rate following radical esophagectomy and poor prognosis in patients with esophageal squamous cell carcinoma receiving preoperative chemoradiotherapy.
Study context
- Population
- Stage III esophageal squamous cell carcinoma patients receiving preoperative chemoradiotherapy followed by esophagectomy, January 2009–December 2017
- Participants
- 111 consecutive patients
- Exposure
- Preoperative neutrophil-to-lymphocyte ratio ≥ 3 vs < 3
- Outcome
- Pulmonary complications following radical esophagectomy
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
P = 0.008
Observational data: associations, not effects.
Further findings
Overall survival · 3 years
P = 0.0026
Disease-free survival · 3 years
P = 0.0055
Postoperative complications, overall (all patients)
- Any postoperative complication
- 75 (68%)
- Pulmonary complications
- 32 (29%)
Other factors associated with pulmonary complications
- Clinical T4 classification
- P = 0.007
- Advanced stage IIIC
- P = 0.012
Oncological stratification (pathological T, N, AJCC stage)
- Preoperative NLR not associated with pathological T, N classification or AJCC stage
Original publication
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