Characteristics, management, and outcomes of patients with infectious encephalitis requiring intensive care: A prospective multicentre observational study
Authors' conclusion
HSV is the primary cause of IE requiring ICU admission. IE patients admitted in ICU have a poor prognosis with 11% of in-hospital mortality and 15% of severe disabilities in survivors at discharge.
Study context
- Population
- Intensive care unit (ICU) patients with infectious encephalitis (IE), French ENCEIF cohort
- Participants
- 198 patients
- Outcome
- Functional status (Glasgow outcome scale (GOS)); poor outcome defined as GOS ≤ 3
- Follow-up
- Hospital discharge
Methodological detailsancillary study of the ENCEIF cohort
- Ancillary study of the ENCEIF cohort
Main finding
As reported in the abstract
Poor outcome (GOS ≤ 3)
Poor outcome at hospital discharge
52
26%
Deaths
22
11%
Observational data: associations, not effects.
Further findings
Cause of IE: HSV
- HSV, n
- 72
- HSV, % of all IE
- 36%
- HSV, % of IE with microbiological documentation
- 53%
Original publication
Characteristics, management, and outcomes of patients with infectious encephalitis requiring intensive care: A prospective multicentre observational study. J Crit Care. Published 17 May 2023. doi:10.
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