ICU sedation, delirium & recovery
Characterization of postintensive care syndrome in a prospective cohort of survivors of COVID-19 critical illness: a 12-month follow-up study
Authors' conclusion
Postintensive care syndrome was common in COVID-19 critical illness survivors and persisted in a significant proportion of patients one year after ICU discharge, impacting HRQoL.
Study context
- Population
- Adult critically ill survivors of SARS-CoV-2 infection, with or without invasive mechanical ventilation, Spain (March 2020 to January 2021)included in final analysis
- Participants
- 142 survivors
- Outcome
- PICS-related sequelae (physical/functional, cognitive, mental health) and HRQoL
- Follow-up
- 12 months after ICU discharge
Methodological detailstelemedicine follow-up, five data collection points, multivariable mixed-effects models
- Telemedicine follow-up
- Five data collection points
- Multivariable mixed-effects models
Main finding
As reported in the abstract
PICS-related sequelae over 12-month follow-up
- Fatigue/dyspnea, pain, impaired muscle function, psychiatric symptomatology and reduced physical health-related quality of life (HRQoL) prominent early after intensive care unit (ICU) discharge
- Functionality and fatigue/dyspnea improved progressively; pain remained stable
- Slight fluctuations in anxiety symptoms and perceived cognitive deficit; Posttraumatic stress disorder (PTSD) and depressive symptoms improved, with a mild rebound at end of follow-up
Observational data: associations, not effects.
Further findings
Risk factors for postintensive care syndrome (PICS)
- Female sex, younger age and need for invasive mechanical ventilation (IMV) were risk factors; higher cognitive reserve a potential protective factor
HRQoL
- Physical HRQoL improved over time; mental HRQoL remained stable
- Shorter ICU stay, better functionality and lower fatigue/dyspnea and pain scores associated with better physical HRQoL; lower anxiety, depression and PTSD scores associated with better mental HRQoL
Original publication
Characterization of postintensive care syndrome in a prospective cohort of survivors of COVID-19 critical illness: a 12-month follow-up study. Can J Anaesth. Published 9 September 2024. doi:10.
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