ICU sedation, delirium & recovery
Evaluating early mobilisation in critically ill COVID-19 patients: Secondary analysis from the European Society of Intensive Care Medicine (ESICM) UNITE-COVID-II multicentre observational study
Primary result · 60-day mortality (EM, combined cohort)Result — go to the resultOdds ratio 0.74 95% CI 0.64–0.86Authors' conclusion
EM is feasible and beneficial for critically ill COVID-19 patients. It was associated with reduced mortality and lower transfer rates to other care facilities
Study context
- Population
- Critically ill ICU patients with confirmed SARS-COV-2 infection103 ICUs in 35 countries
- Participants
- 2,053 vs 4,190
- Comparison
- Early mobilisation vs no early mobilisation; second vs first COVID-19 wave
- Second waven = 2,053
- First waven = 4,190reference
- Primary endpoint
- Association between EM (within first 72 h of ICU admission) and outcomes
- Follow-up
- 60 days
Primary result
60-day mortality (EM, combined cohort)
Odds ratio
0.74
95% CI 0.64–0.86
P = 0.001
EM vs No EM
OR 0.74 (95% CI 0.64–0.86); P = 0.001
As reported in the abstract
Further findings
EM achieved
P < 0.001
Likelihood of early mobilisation (EM) with mechanically ventilated (MV) on admission (combined cohort)
| OR (95% CI) | P value | ||
|---|---|---|---|
| MV on admission | 0.29 (0.25–0.33) | P = 0.001 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Transfer to other care facilities (EM)EM vs No EM | 0.74 (0.59–0.94) | P = 0.001 | |
| 0.512Odds ratio (log scale) |
ICU and hospital LOS (EM)
- EM did not improve ICU or hospital LOS
Original publication
Evaluating early mobilisation in critically ill COVID-19 patients: Secondary analysis from the ESICM UNITE-COVID-II multicentre observational study. Anaesth Crit Care Pain Med. Published 17 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →