ICU sedation, delirium & recovery
Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study
Authors' conclusion
Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility.
Study context
- Population
- Critically ill COVID-19 patients in the ICU, February 15th–May 15th, 2020
- Participants
- 4,190 patients · 280 ICUs · 45 countries
- Comparison
- Early mobilisation (EM) vs no EM
- EMn = 1,114
- No EMn = 3,076reference
Methodological detailspre-planned subanalysis, international multicentre
- Pre-planned subanalysis
- International multicentre
Primary result
As reported in the abstract
Initiation of EM · within 72 h of ICU admission
- Patients receiving EM
- 1114 (26.6%)
- Mechanical ventilation at admission, negatively associated with EM: OR
- 0.29 (95% CI 0.25, 0.35; p = 0.001)
- Higher age, negatively associated with EM: OR
- 0.99 (95% CI 0.98, 1.00; p ≤ 0.001)
- Pre-existing asthma, negatively associated with EM: OR
- 0.84 (95% CI 0.73, 0.98; p = 0.028)
- Pre-existing kidney disease, negatively associated with EM: OR
- 0.84 (95% CI 0.71, 0.99; p = 0.036)
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Discharge homeAdjusted for covariates | 1.31 (1.08–1.58) | P = 0.007 | |
| MortalityAdjusted for covariates | 0.88 (0.7–1.09) | P = 0.24 | |
| 0.512Odds ratio (log scale) |
| Outcome | Adj. difference (days) (95% CI) | P value | |
|---|---|---|---|
| ICU LOSAdjusted for covariates | 0.91 (- 0.47, 1.37) | P = 0.34 | |
| Hospital LOSAdjusted for covariates | 1.4 (- 0.62, 2.35) | P = 0.24 | |
| −10123Difference, days (linear scale) |
Original publication
Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study. Ann Intensive Care. Published 14 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →