ICU sedation, delirium & recovery
Frailty in the prediction of delirium in the intensive care unit: A secondary analysis of the Deli study
Authors' conclusion
We have been able to show that both the cumulative deficits frailty index and clinical frailty scale predict an acute episode of delirium among adults admitted to intensive care.
Study context
- Population
- Adults admitted to four adult ICUs in south-west Sydney, Australia, May 2019–February 2020
- Participants
- 2,566 adults
- Comparison
- Cumulative deficit frailty index vs Clinical frailty scale
- Primary endpoint
- Ability to predict an acute episode of delirium in the ICU (discrimination)
Methodological detailsprognostic/prediction analysis, bootstrap approach, multicentre (four adult ICUs), Nomograms to individualise absolute risk of delirium presented
- Prognostic/prediction analysis
- Bootstrap approach
- Multicentre (four adult ICUs)
- Nomograms to individualise absolute risk of delirium presented
Primary result
As reported in the abstract
Discrimination of delirium in the ICU
| Group | AUC |
|---|---|
| Cumulative deficit frailty index | 0.701 |
| Clinical frailty scale | 0.703 |
AUC
Cumulative deficit frailty index0.701
Clinical frailty scale0.703
Further findings
Reclassification of risk with frailty index added to age, sex and APACHE III model
- Addition of a frailty index resulted in net reclassification of risk
Original publication
Frailty in the prediction of delirium in the intensive care unit: A secondary analysis of the Deli study. Acta Anaesthesiol Scand. Published 30 October 2023. doi:10.
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