ICU sedation, delirium & recovery
The Varying Impact of Frailty With Increasing Body Mass Index on Survival Up To 3 Years After ICU Admission: A Retrospective Registry-Based Study
Authors' conclusion
The association between frailty and outcomes after critical illness differed across BMI categories with a larger increase in the risk of mortality noted at higher BMI levels.
Study context
- Population
- Adults ≥16 years admitted to 1170 ICUs (Australia New Zealand Intensive Care Society Adult Patient Database) with documented Clinical Frailty Scale (CFS) and body mass index (BMI), January 1, 2018 to March 31, 202249,070 (17.4%) frail
- Participants
- 282,586 adults
- Exposure
- Frailty vs no frailty, across BMI categories
- Frailn = 49,070
- Outcome
- Survival up to 3 years following ICU admission
- Follow-up
- Up to 3 years
Methodological detailsmulticentre, registry-based, observational
- Multicentre
- Registry-based
- Observational
Main finding
3-year survival
HR for mortality
1.67
95% CI 1.62–1.73
By group
Frail vs Not frail
HR for mortality 1.67 (95% CI 1.62–1.73)
As reported in the abstract
Observational data: associations, not effects.
Further findings
- Frailty prevalence, BMI <18.5 kg/m²
- 34.8%
- Frailty prevalence, BMI ≥40 kg/m²
- 18.8%
- Frailty less frequent as BMI increased, more prevalent again at BMI ≥40 kg/m²
Original publication
The Varying Impact of Frailty With Increasing Body Mass Index on Survival Up To 3 Years After ICU Admission: A Retrospective Registry-Based Study. Crit Care Med. Published 10 July 2025. doi:10.
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