Chemical hip denervation using phenol via Pericapsular Nerve Group (PENG) block in palliative non-operative management for frail older hip fracture patients: A multicenter retrospective cohort study
Authors' conclusion
Chemical hip denervation with phenol via PENG block may be a viable analgesic option in selected frail older hip fracture patients as part of person-centered, multidisciplinary palliative care.
Study context
- Population
- Frail patients aged ≥70 y with hip fracture in palliative non-operative management, 6 hospitals, Netherlands, Jan 2022–Aug 2023
- Participants
- 185 patients · 6 hospitals
- Outcome
- Post-procedural pain experience (acceptable at rest and during care)
Methodological detailsmulticentre, Phenol mostly 6 % (70 % of patients) or 10 % (23 %); median volume 10 ml (p25 - p75 8-10), Median age 87 years (p25 - p75 82-91); cognitive impairment 74 %; dependent on daily care 88 %
- Multicentre
- Phenol mostly 6 % (70 % of patients) or 10 % (23 %); median volume 10 ml (p25 - p75 8-10)
- Median age 87 years (p25 - p75 82-91); cognitive impairment 74 %; dependent on daily care 88 %
Main finding
As reported in the abstract
Post-procedural pain experienced as acceptable
Rest-related pain acceptable
89 %
Care-related pain acceptable
65 %
Observational data: associations, not effects.
Secondary outcomes
Pain (numeric rating scale (NRS)) and morphine milligram equivalents (MME)
- NRS pain and MME were low
Mobility
- Mobility remained limited
Survival
- Median survival, days (p25 - p75 4-22)
- 9
Variation by fracture type and hospital location
- Significant differences observed in fracture type and hospital location
Safety
- No complications or adverse treatment effects reported
Original publication
Chemical hip denervation using phenol via Pericapsular Nerve Group (PENG) block in palliative non-operative management for frail older hip fracture patients: A multicenter retrospective cohort study. J Clin Anesth. Published 27 May 2025. doi:10.
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