Pediatric anesthesia & critical care
Chest compressions for pediatric organized rhythms: A hemodynamic and outcomes analysis
Primary result · ROSC by pre-CPR pulse pressure ≥ 20 mmHgResult — go to the resultAdjusted relative risk 1.58 95% CI 1.07–2.35Authors' conclusion
A pre-CPR pulse pressure >20 mmHg was associated with improved patient outcomes.
Study context
- Population
- Pediatric patients receiving cardiopulmonary resuscitation (CPR), stratified by age (≤1 year, >1 year)
- Comparison
- BRADY vs pulseless electrical activity (PEA)
- Primary endpoint
- Return of spontaneous circulation (ROSC)
Methodological detailsprospective observational cohort
- Prospective observational cohort
Primary result
ROSC by pre-CPR pulse pressure ≥ 20 mmHg
Adjusted relative risk
1.58
95% CI 1.07–2.35
P = 0.022
Pre-CPR hemodynamics in bradycardia with poor perfusion vs PEA, and association with outcomes
aRR 1.58 (95% CI 1.07–2.35); P = 0.022
As reported in the abstract
Further findings
Pre-CPR pulse pressure, ≤1 year · prior to CPR
Survival to discharge with favorable neurologic outcome, by pre-CPR pulse pressure ≥ 20 mmHg · hospital discharge
| aRR (95% CI) | P value | ||
|---|---|---|---|
| BRADY, pulse pressure ≥ 20 mmHg | 1.28 (1.01–1.62) | P = 0.040 | |
| PEA, pulse pressure ≥ 20 mmHg | 1.94 (1.19–3.16) | P = 0.008 | |
| 0.20.5125Adjusted relative risk (log scale) |
| Outcome | BRADY | PEA |
|---|---|---|
| Pre-CPR HR, by age · prior to CPR | ||
| ≤1 year | 63.8 [46.5, 87.0] | 120 [93.2, 150.0] |
| >1 year | 67.4 [54.5, 87.0] | 100 [66.7, 120] |
- Pre-CPR HR, by age: ≤1 year p < 0.001
- Pre-CPR HR, by age: >1 year p < 0.014
- Pre-CPR pulse pressure, ≤1 year: p > 0.001
Original publication
Chest compressions for pediatric organized rhythms: A hemodynamic and outcomes analysis. Resuscitation. Published 3 December 2023. doi:10.
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