Pediatric anesthesia & critical care
A Novel Preoperative Risk Score Incorporating Non‐Invasive Hemodynamics to Predict Prolonged Mechanical Ventilation in Infants Undergoing Ventricular Septal Defect (VSD) Repair
Authors' conclusion
A composite risk score integrating individual data and EC hemodynamics monitoring can effectively identify infants at high risk for PMV following VSD repair.
Study context
- Population
- Infants undergoing VSD repair with concurrent respiratory compromise
- Participants
- 51 infants
- Outcome
- Prediction of prolonged mechanical ventilation (≥ 12 h) by preoperative EC hemodynamic data
Methodological detailsleave-one-out cross-validation
- Leave-one-out cross-validation
Performance
As reported in the abstract
Prolonged mechanical ventilation (≥ 12 h)
| Test or model | R | P | AUC | Sensitivity | Specificity | Leave-One-Out Cross-Validation (LOOCV) AUC |
|---|---|---|---|---|---|---|
| Principal Component Analysis (PCA)-derived composite score | −0.522 | p < 0.001 | 0.856 | 0.857 | 0.773 | 0.830 |
Principal Component Analysis (PCA)-derived composite score
R−0.522
Pp < 0.001
AUC0.856
Sensitivity0.857
Specificity0.773
Leave-One-Out Cross-Validation (LOOCV) AUC0.830
Further findings
Parameters correlating with clinical classifications of cardiac dysfunction
- NT-proBNP: r
- 1.517
- NT-proBNP: OR
- 4.560
- ∆ICON: r
- 1.470
- ∆ICON: OR
- 4.350
- p < 0.05
Original publication
A Novel Preoperative Risk Score Incorporating Non‐Invasive Hemodynamics to Predict Prolonged Mechanical Ventilation in Infants Undergoing VSD Repair. Paediatr Anaesth. Published 12 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →