Pediatric anesthesia & critical care
Effect of the Duration of Cardiopulmonary Bypass on Oxygenation Predicted by Measuring Thoracic Fluid Content Using Electrical Cardiometry in Infants Undergoing Closure of Ventricular Septal Defect:A Prospective Observational Study
Authors' conclusion
Prolonged CPB is associated with greater thoracic fluid accumulation and impaired oxygenation in infants undergoing VSD closure. However, the relationship between CPB duration, ΔTFC, and pulmonary dysfunction appeared multifactorial and was influenced by perioperative inflammatory and fluid-related variables.
Study context
- Population
- Infants (1–12 months) undergoing elective ventricular septal defect (VSD) closure with cardiopulmonary bypass (CPB)
- Participants
- 30 infants
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- CPB duration vs ΔTFC, correlation r
- 0.50
- CPB duration vs ΔTFC, P
- p = 0.0045
- CPB duration vs ΔP/F, correlation r
- −0.60
- CPB duration vs ΔP/F, P
- p = 0.0005
- CPB duration vs dynamic compliance, correlation r
- −0.48
- CPB duration vs dynamic compliance, P
- p = 0.007
Observational data: associations, not effects.
Further findings
Discrimination of postoperative oxygenation impairment (P/F <300), ROC
- ΔTFC AUC
- 0.91
- CPB duration AUC
- 0.92
- Optimal ΔTFC threshold
- ≥13 kΩ-1
- Optimal CPB duration threshold
- ≥84 minutes
Postoperative P/F ratio, multivariate linear regression (adjusted for IL-6, prime volume/kg, transfusion/kg, conventional ultrafiltration)
- ΔTFC independently predicted P/F ratio, β
- −5.68
- ΔTFC, P
- P = 0.013
- CPB duration not independently associated
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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