Paediatric anaesthesia & critical care
Childhood Exposure to General Anesthesia For Surgery: Identification of a Subtle Post-Operative Cognitive Phenotype.
Main finding · Executive function performance (main effect of general anesthesia exposure, linear mixed-effects model)Result — go to the resultΧ²(1) .01Authors' conclusion
Early childhood exposure to general anesthesia was not associated with reduced overall executive function. However, a potential post-operative cognitive phenotype is suggested by a reduced likelihood to belong to an efficient executive control profile with greater visuo-spatial global-local precedence.
Study context
- Population
- Children aged 9–11 years, with or without prior general anesthesia exposure for surgerychildren who completed the cognitive battery
- Participants
- 77 children
- Exposure
- Children with vs without prior general anesthesia exposure for surgery
- Outcome
- Executive function performance (main effect of general anesthesia exposure, linear mixed-effects model)
Main finding
As reported in the abstract
Χ²(1)
.01
P = 0.92
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Odds of belonging to the Efficient profile groupLower odds with general anesthesia exposure | 0.71 (0.705–0.710) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
| Outcome | Estimate (95% CI) | P value |
|---|---|---|
| Visuo-spatial attention: Global-Local precedence measuresHigher in GA-exposed participants | 0.53 (0.04–1.01) | P = 0.036 |
Executive function profiles (exploratory latent profile analysis)
- Two executive function profiles identified: Efficient and Vulnerable Executive Control
- Exploratory
Original publication
Childhood Exposure to General Anesthesia For Surgery: Identification of a Subtle Post-Operative Cognitive Phenotype. Anesthesiology. Published 21 October 2026. doi:10.
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