Pediatric anesthesia & critical care

Choice of creep or maintenance fluid type and their impact on total daily intensive care unit (ICU) sodium burden in critically ill patients: A systematic review and meta-analysis

J Crit CarePublished Systematic review and meta-analysis of controlled clinical trials

Pooled result · Mean daily sodium reductionResult — go to the resultMean daily sodium reduction 117 mmol 95% CI −174 to −59

Authors' conclusion

Using low sodium content maintenance/creep fluids substantially reduces daily sodium burden in adult ICU patients.

Study context

Population
Adult ICU patients (trials on resuscitation fluids, ED-only and pediatric excluded)
Participants
1,105 patients · 5 studies
Comparison
Low vs high sodium content maintenance/creep fluids
Outcome
Reduction in mean total sodium intake

Pooled result

Mean daily sodium reduction

Mean daily sodium reduction

117 mmol

95% CI −174 to −59

P < 0.001

As reported in the abstract

Further pooled results

OutcomeOR (95% CI)
Hyperchloremia0.26 (0.1–0.64)

Hyper-/hyponatremia and fluid balances

No differences in incidences of hyper-/hyponatremia and fluid balances

Original publication

Choice of creep or maintenance fluid type and their impact on total daily ICU sodium burden in critically ill patients: A systematic review and meta-analysis. J Crit Care. Published 29 August 2023. doi:10.1016/j.jcrc.2023.154403

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