Clinical applications for the endotoxin activity assay in sepsis: a scoping review
Authors' conclusion
Our results highlight the clinical application of EAA measurement in sepsis patient populations worldwide, particularly its potential role in the application of blood purification therapy.
Study context
- Population
- Human sepsis subjects (adult and pediatric) with Endotoxin Activity Assay (EAA) measurementstudies on sepsis
- Participants
- 54 subjects
- Outcome
- EAA usage trends and clinical applications in sepsis
Methodological detailsfour databases (Embase, Web of Science, MEDLINE, Cochrane Library), search to May 2025
- Four databases (Embase, Web of Science, MEDLINE, Cochrane Library)
- Search to May 2025
Main finding
As reported in the abstract
- Articles applying EAA in human patients
- 95
- Studies focused on sepsis
- 54
- Studies conducted in Europe
- 51.9%
- Studies conducted in Asia
- 22.2%
- Studies conducted in North America
- 11.1%
- RCTs (endotoxin adsorption, CRRT with adsorption filters for septic shock; EAA ≥ 0.6 in inclusion criteria)
- 3
- Studies measuring EAA more than twice per patient
- 48.1%
Original publication
Clinical applications for the endotoxin activity assay in sepsis: a scoping review. Crit Care. Published 30 January 2026. doi:10.
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