Pediatric anesthesia & critical care
Clinical effectiveness of perioperative oxygen therapy strategies in children: a systematic review and meta-analysis of randomised controlled trials
Authors' conclusion
Current evidence does not support the routine use of any specific paediatric perioperative oxygen strategy.
Study context
- Population
- Paediatric patients undergoing surgical procedures
- Participants
- 1,337 patients · 16 trials
- Comparison
- High FiO2 vs Low FiO2 vs high-flow nasal oxygen (HFNO) vs conventional oxygen therapy (COT) vs noninvasive ventilation (NIV)
- Outcome
- Surgical site infection (intraoperative high vs low fraction of inspired oxygen (Fio2))
Methodological detailsrandom effects models, GRADE certainty assessment
- Random effects models
- GRADE certainty assessment
Pooled result
As reported in the abstract
Relative risk (95% CI)
High Fio2 vs Low Fio2
0.75(0.33–1.73)
RD (95% CI)
High Fio2 vs Low Fio2
−3%(−7.9% to +8.6%)
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Pneumothorax (HFNO vs NIV, postoperative)RD −0.5% (−5.9% to +45.1%) · very uncertain evidence | 0.92 (0.11–7.76) | |
| 0.10.31310Relative risk (log scale) |
Original publication
Clinical effectiveness of perioperative oxygen therapy strategies in children: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. Published 6 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →