Cardiac arrest & resuscitation
Clinical heterogeneity and phenotyping of post cardiac arrest brain injury: one size may not fit all
Authors' conclusion
It is therefore increasingly clear that this approach to PCABI is insufficient.
Study context
- Population
- Patients with post-cardiac arrest brain injury (PCABI)
Main finding
As reported in the abstract
- Traditional stratification of PCABI by simple historical characteristics (e.g. location of cardiac arrest, initial rhythm, witnessed vs unwitnessed) inadequately reflects in vivo PCABI severity or responses to interventions
- Proposes a shift to expeditious phenotyping of PCABI severity, assessing in vivo severity and patterns of injury (pathophysiology, selective anatomical vulnerability, electrographic patterns) for future targeted therapies
Original publication
Clinical heterogeneity and phenotyping of post cardiac arrest brain injury: one size may not fit all. Intensive Care Med. Published 16 July 2025. doi:10.
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