Cardiac arrest & resuscitation
Impact of frailty on mortality, functional outcome, and health status after out-of-hospital cardiac arrest: insights from the TTM2-trial
Authors' conclusion
Frailty was associated with a significantly increased risk of mortality and poor functional outcome after out-of-hospital cardiac arrest. Findings suggest more frequent functional decline and lower overall health status in frail survivors.
Study context
- Population
- Participants after OHCA in the TTM2 trial188 (10%) frail or severely frail
- Participants
- 1,861 participants
- Comparison
- Prefrail, frail and severely frail vs fit
- Prefrailn = 240
- Primary endpoint
- Mortality and poor functional outcome (modified Rankin Scale 4-6)
- Follow-up
- 6 and 24 months
Methodological detailscohort-based, international, prospective, multicentre
- Cohort-based
- International
- Prospective
- Multicentre
Primary result
As reported in the abstract
6 month mortality · 6 months
Each group vs fitAdjusted odds ratio (95% CI)
Prefrail
2.7(1.8–3.8)
Frail
3.7(1.9–7.1)
Severely frail
8.9(4.2–18.7)
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Poor functional outcome · 6 monthsPrefrail vs Fit | 2.9 (1.9–4.2) | |
| Poor functional outcome · 6 monthsFrail vs Fit | 3.9 (1.9–8.1) | |
| Poor functional outcome · 6 monthsSeverely frail vs Fit | 35.4 (8.4–148.8) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Neuroprognostication and withdrawal-of-life-sustaining-therapies (WLST)
- Severely frail underwent neuroprognostication less often
- P < 0.001
- WLST more common in prefrail, frail and severely frail
- P < 0.001
Functional decline and health status in survivors
- Prefrail and frail survivors tended to report more frequent functional decline and lower health status, with individual variation
Original publication
Impact of frailty on mortality, functional outcome, and health status after out-of-hospital cardiac arrest: insights from the TTM2-trial. Intensive Care Med. Published 10 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →