Cardiac arrest & resuscitation
Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study
Primary result · SurvivalResult — go to the resultRR for survival 0.96 95% CI 0.81–1.15Authors' conclusion
In this study, hypothermia at 33˚C did not improve survival or functional outcome in a subset of patients with similar cardiac arrest characteristics to patients in whom benefit from hypothermia was shown in prior studies.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients in TTM-2 with characteristics similar to patients in one previous randomised trial showing benefit for hypothermiaof 1891 in TTM-2
- Participants
- 600 patients
- Comparison
- Hypothermia at 33 °C vs normothermia
- Hypothermian = 294
- Normothermian = 306reference
- Primary endpoint
- Survival
- Follow-up
- 6 months
Methodological detailspost hoc analysis, pragmatic, multicentre
- Post hoc analysis
- Pragmatic
- Multicentre
Primary result
As reported in the abstract
RR for survival
0.96
95% CI 0.81–1.15
P = 0.71
Events by treatment group
Hypothermia vs Normothermia
RR for survival 0.96 (95% CI 0.81–1.15); P = 0.71
Secondary outcomes
| Outcome | Hypothermia | Normothermia | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Favorable functional outcome (modified Rankin scale 0-3) · 6 months | 67.3% | 66.0% | 1.03 (0.87–1.23) | P = 0.79 | |
| 0.512Relative risk (log scale) |
Safety
| Outcome | Hypothermia | Normothermia | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Arrhythmias | 21.2% | 14.1% | 1.49 (1.05–2.14) | P = 0.026 | |
| 0.512Odds ratio (log scale) |
Original publication
Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study. Crit Care. Published 15 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →