Cardiac arrest & resuscitation
On-scene selective brain cooling in ventricular fibrillation cardiac arrest: pilot results from the PRINCESS2 randomised trial
Authors' conclusion
In this pilot phase of the PRINCESS2 trial, on-scene trans-nasal cooling in OHCA patients with shockable rhythms was performed with high protocol adherence without safety concerns.
Study context
- Population
- Out-of-hospital cardiac arrest (OHCA) patients with initial shockable rhythmfirst 100 of 1,022 planned
- Participants
- 100 patients
- Comparison
- Intervention vs Control
- Interventionn = 50
- Controln = 50reference
- Primary endpoint
- Adherence to treatment allocation and protocol in the prehospital and in-hospital stages (pilot outcome)
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Adherence to allocation and treatment protocol
Intervention
50
events
Control
48
events
- Overall adherence to allocation and treatment protocol
- 92%
- Intervention: minor trans-nasal cooling interruptions
- 4
- Intervention: systemic cooling interruptions
- 2
- Control: crossed over to cooling
- 2
Further findings
Survival to 72 h
- Survival to 72 h: control 31/49; 1 control lost to follow-up
Safety
Prehospital re-arrest
- Prehospital re-arrest: 11/49 vs 9/40
Device-related serious adverse events
- No device-related serious adverse events occurred
Adverse events within 7 days
- Similar adverse event rates
Original publication
On-scene selective brain cooling in ventricular fibrillation cardiac arrest: pilot results from the PRINCESS2 randomised trial. Crit Care. Published 12 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →