Clinical outcomes in combination versus mono antibiotic therapy in intensive care unit (ICU) admitted patients with a suspected infection - A substudy of the DIANA study
Authors' conclusion
This study found no differences in clinical cure and mortality between empirical combination versus mono therapy in a large cohort of ICU patients with a suspected infection.
Study context
- Population
- Adults admitted to the ICU with suspected or confirmed infection
- Participants
- 1,398 adults
- Exposure
- Combination vs mono empirical antibiotic therapy
- Combinationn = 568
- Outcome
- Clinical cure (survival and resolution of all signs and symptoms related to the infection)
- Follow-up
- Day 7
Methodological detailssubstudy of the DIANA study
- Substudy of the DIANA study
Main finding
As reported in the abstract
Clinical cure
Clinical cure, all patients
641
46%
Observational data: associations, not effects.
Further findings
Mortality · day 7 and 28
- Died by day 7, all patients
- 135 (10%)
- No significant association between combination and mono therapy and mortality
Original publication
Clinical outcomes in combination versus mono antibiotic therapy in ICU admitted patients with a suspected infection - A substudy of the DIANA study. J Crit Care. Published 20 December 2023. doi:10.
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