Clinical significance of human metapneumovirus detection in critically ill adults with lower respiratory tract infections
Authors' conclusion
This preliminary work suggested that hMPV may be associated with severe infection and high mortality in patients with underlying malignancies.
Study context
- Population
- Adults with human metapneumovirus (hMPV) infection; cohort of intensive care unit (ICU) admissions, January 1, 2010–June 30, 2018
- Participants
- 1,849 adults · 69 studies
- Comparison
- hMPV vs matched influenza infected patients; hMPV infections in adults
- hMPVn = 26
- Outcome
- Rate of lower respiratory tract infections (low respiratory tract infections (LRTIs)) among all hMPV infected patients
Methodological detailsmonocentric, matched case-control analysis vs influenza
- Monocentric
- Matched case-control analysis vs influenza
Pooled result
As reported in the abstract
Rate of hMPV LRTIs (meta-analysis)
hMPV
45%
95% CI 31–60%
Further pooled results
ICU admission (meta-analysis)
- ICU admission required
- 33%
- 95% CI 21-45%
- I2 = 99%
Hospital mortality (meta-analysis)
- Hospital mortality rate
- 10%
- 95% CI 7-13%
- I2 = 83%
ICU mortality (meta-analysis)
- ICU mortality rate
- 23%
- 95% CI 12-34%
- I2 = 65%
Predictors of mortality (meta-analysis)
- Underlying malignancy independently associated with increased mortality
ICU cohort: ICU admission among hMPV-positive patients
- Admitted to ICU (of 402 hMPV-positive)
- 26 (6.5%)
- Admitted for acute respiratory failure
- 19 (4.7%)
- Immunocompromised
- 24 (92%)
- Bacterial coinfections
- 53.8%
- Hospital mortality
- 30.8%
- Retrospective monocentric cohort
ICU cohort: hMPV vs matched influenza (case-control)
- Clinical and imaging characteristics not different between hMPV and influenza
Original publication
Clinical significance of human metapneumovirus detection in critically ill adults with lower respiratory tract infections. Ann Intensive Care. Published 20 March 2023. doi:10.
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